Preparation technology and detection method of medicinal magnesium oxide

According to the requirements of the pharmaceutical and food industry for magnesium oxide, Hebei Messi Biology Co., Ltd. proposed to use the brine-ammonia method to produce medicinal magnesium oxide, and remove the impurity ions in the brine that affect the product quality with a simple method. Up to the national standard.

Using magnesite ore, ammonium bicarbonate, and sulfuric acid as raw materials, the metathesis method is adopted, the mother liquor is fully circulated, the neutralization, dissolution, ammonia absorption, and metathesis reaction mechanisms are effectively used, and the process conditions are optimized. , establish a production quality management assurance system, strict operating procedures, improve the utilization rate of raw materials, reduce production costs, reduce the discharge of three wastes, advanced and reasonable technology, do not add any impurity removers, remove metal ion impurities. The production of medical oxidation Magnesium, stable and uniform quality, safe and reliable, has been well received by the pharmaceutical industry.

A flame atomic absorption spectrometry method was established to determine the amount of calcium oxide in magnesium oxide, a pharmaceutical excipient, and the method for the determination of calcium oxide in magnesium oxide and light magnesium oxide in the fourth volume of \”Chinese Pharmacopoeia\” 2020 edition was improved.

Method: In hydrochloric acid solution medium, using flame atomizer, calcium-hollow cathode lamp (Heraeus), detection wavelength: 422.7 nm, slit width: 0.5 nm, lamp current: 10 mA, flame type: air-acetylene. The established method was investigated methodologically and compared with the titration results.

Results: In the concentration range of 0-15 μg·mL-1, the linear relationship of calcium ion was good (r=0.9988, n=4), the precision RSD was 0.9% (n=6), and the repeatability RSD was 2.2% (n =6), the average recovery rate was 94.3%. Calcium oxide in 19 batches of samples was determined, and the results were all less than 0.8%. The determination results of AAS method were higher than those of titration method.

Conclusion: After method verification and results comparison analysis, the method has high accuracy and can meet the determination of calcium oxide in magnesium oxide, a pharmaceutical excipient. It is suggested that the limit of calcium oxide in the first supplement of the 2020 edition of the \”Chinese Pharmacopoeia\” be revised to no more than 1.5%.