Hebei Messi Biology Co., Ltd. stated that anhydrous magnesium carbonate can be used as a carrier in medicines. The magnesite ore is broken into pieces and put into a multi-position parallel reaction synthesizer flask. Water is added and carbon dioxide is introduced at the same time. Prepare magnesium bicarbonate, magnesium bicarbonate and magnesium hydroxide as cisplatin drug carriers. Through the drug loading mechanism, the drug can be transported into the tumor cell tissue, promote the dissolution and dispersion of cisplatin in the tumor cell fluid, and exert an effect on the cells. It has an inhibitory effect, moderately increases the cytotoxicity of cisplatin, and at the same time has a strong biological interaction with the targeted DNA molecules.
In order to explore ways to improve the solubility of poorly soluble drugs through drug carrier delivery, drugs with different structures were loaded into mesoporous magnesium carbonate (MMC) and characterized through porosity, drug release curve, and crystallinity methods to determine the mesoporous carbonic acid. Magnesium can be used as a drug carrier to improve the solubility of poorly soluble compounds. Amorphous mesoporous magnesium carbonate is used as a drug carrier, and two poorly water-soluble drugs, benzenesulfonic acid and rimonabant, are loaded in MMC to enhance the water solubility of these two drugs and increase the drug release rate.
Magnesium carbonate is prepared by reacting magnesium oxide and carbon dioxide, and ibuprofen is diffused onto the mesoporous magnesium carbonate through the impregnation method. The drug release rate is controlled by adjusting the particle size of the carrier particles, and the water solubility of poorly soluble drugs can be improved.